collapse
2020 Donation Drive

It's time for our annual Server Donation Drive! We need to raise at least $710 to keep The Cauldron's server online for another year. Please help! Either hit that Paypal button to the right and make a one-time donation in any amount or set up a monthly Bronze, Silver or Gold Donor subscription. You can find more info in this message!

Donations as of 25 October 2020: $610 donated. Only $100 more needed! Thank you, donors!


Note: This total is updated manually, usually once a day


* Recent Posts

Re: Struggling Family of 5 by Cass Family
[Today at 01:06:32 am]


Re: Struggling Family of 5 by Jenett
[Today at 12:58:01 am]


Struggling Family of 5 by Cass Family
[Yesterday at 11:43:45 pm]


Re: Prayers for my lap band surgery by anubisa
[Yesterday at 06:48:40 pm]


Re: Developing and Nurturing a Positive Mindset by Ashmire
[Yesterday at 02:17:02 pm]

Author Topic: Ketamine has been found to help with depression  (Read 770 times)

TheGreenWizard

  • Master Member
  • ******
  • Join Date: Jul 2017
  • Location: New York, NY
  • Posts: 304
  • Country: us
  • Total likes: 119
    • View Profile
  • Religion: Hellenic Pagan
  • Preferred Pronouns: he/him/his
Ketamine has been found to help with depression
« on: July 03, 2020, 02:04:54 pm »
"A lack of neural plasticity in the hippocampus has been implicated in the development of depression. Ketamine is able to restore hippocampal plasticity in a rat model of depression, potentially illustrating a mechanism for the drug's anti-depressant effects"
Some key takeaways:
  • Accumulating evidence suggests that dysregulation of neural plasticity in the hippocampus contributes to the pathophysiology of depression
  • This study was conducted to explore the anti-depressant effects of ketamine in mice - specifically if ketamine is able to impact neural plasticity of the hippocampus
  • The results show that Ketamine was able to restore synaptic plasticity in the dorsal hippocampus of mice - indicating that it may be able to reverse the stress-induced lack of plasticity seen in depression
To read more about this study, please click here for the link.
“You have brains in your head. You have feet in your shoes. You can steer yourself any direction you choose. You're on your own. And you know what you know. And YOU are the one who'll decide where to go...”
― Dr. Seuss, Oh, the Places You'll Go

Sophia C

  • Adept Member
  • ********
  • Join Date: Aug 2012
  • Location: London, UK
  • *
  • Posts: 2000
  • Country: gb
  • Total likes: 44
    • View Profile
    • http://leithincluan.wordpress.com/
  • Religion: Pagan and Christian heretic. Anglican, Druid, Gaelic-ish polytheist, some other influences
  • Preferred Pronouns: They/them
Re: Ketamine has been found to help with depression
« Reply #1 on: July 03, 2020, 02:20:21 pm »
"A lack of neural plasticity in the hippocampus has been implicated in the development of depression. Ketamine is able to restore hippocampal plasticity in a rat model of depression, potentially illustrating a mechanism for the drug's anti-depressant effects"
Some key takeaways:
  • Accumulating evidence suggests that dysregulation of neural plasticity in the hippocampus contributes to the pathophysiology of depression
  • This study was conducted to explore the anti-depressant effects of ketamine in mice - specifically if ketamine is able to impact neural plasticity of the hippocampus
  • The results show that Ketamine was able to restore synaptic plasticity in the dorsal hippocampus of mice - indicating that it may be able to reverse the stress-induced lack of plasticity seen in depression
To read more about this study, please click here for the link.

Previous studies have shown this too, in humans, together with its positive effects for anxiety. It's pretty widely known by the medical establishment (although possibly not this specific mechanism of treatment). Summary of more studies here. https://www.psychiatryadvisor.com/home/topics/anxiety/ketamine-a-promising-novel-therapy-for-anxiety-and-ptsd/

It seems to work very differently from most medication for depression and anxiety, with a 10-ish day effect that then wears off entirely. My guess is that it will never be widely prescribed due to how controversial it is, but maybe I'll be proven wrong...
"We're all stories, in the end. Make it a good one, eh?"
- Doctor Who

Sefiru

  • Senior Staff
  • *
  • Join Date: Nov 2013
  • Location: In the walls
  • Posts: 2082
  • Country: ca
  • Total likes: 500
    • View Profile
Re: Ketamine has been found to help with depression
« Reply #2 on: July 03, 2020, 06:41:40 pm »
It seems to work very differently from most medication for depression and anxiety, with a 10-ish day effect that then wears off entirely. My guess is that it will never be widely prescribed due to how controversial it is, but maybe I'll be proven wrong...

Just wait until the herbal supplement crowd gets hold of it ...

Castus

  • Sr. Master Member
  • *******
  • Join Date: Jul 2011
  • Location: Virginia
  • Posts: 822
  • Country: us
  • Total likes: 76
    • View Profile
  • Religion: that’s a great question
Re: Ketamine has been found to help with depression
« Reply #3 on: July 05, 2020, 09:13:47 am »
"A lack of neural plasticity in the hippocampus has been implicated in the development of depression. Ketamine is able to restore hippocampal plasticity in a rat model of depression, potentially illustrating a mechanism for the drug's anti-depressant effects"
Some key takeaways:
  • Accumulating evidence suggests that dysregulation of neural plasticity in the hippocampus contributes to the pathophysiology of depression
  • This study was conducted to explore the anti-depressant effects of ketamine in mice - specifically if ketamine is able to impact neural plasticity of the hippocampus
  • The results show that Ketamine was able to restore synaptic plasticity in the dorsal hippocampus of mice - indicating that it may be able to reverse the stress-induced lack of plasticity seen in depression
To read more about this study, please click here for the link.

Yeah no shit lmao. Ketamine has different effects on different people ofc, and it can be tricky to avoid falling into the hellish purgatory of a k-hole, but it definitely has its merits in this area. I, too, doubt that it’ll hit the mainstream for mental health purposes, but it’s always nice and validating to see studies like these.
“Castus, meanwhile, goes straight for the bad theology like one of those creepy fish that swims up streams of pee.” — Darkhawk

Sophia C

  • Adept Member
  • ********
  • Join Date: Aug 2012
  • Location: London, UK
  • *
  • Posts: 2000
  • Country: gb
  • Total likes: 44
    • View Profile
    • http://leithincluan.wordpress.com/
  • Religion: Pagan and Christian heretic. Anglican, Druid, Gaelic-ish polytheist, some other influences
  • Preferred Pronouns: They/them
Re: Ketamine has been found to help with depression
« Reply #4 on: July 05, 2020, 11:37:54 am »
Yeah no shit lmao. Ketamine has different effects on different people ofc, and it can be tricky to avoid falling into the hellish purgatory of a k-hole, but it definitely has its merits in this area. I, too, doubt that it’ll hit the mainstream for mental health purposes, but it’s always nice and validating to see studies like these.

I take an *incredibly* small dose orally (for chronic pain - prescribed by a pain clinic). I don’t even get a high, never mind the very negative side effects like that. I think if doctors worked with it, they could get it to work for people without problems. Unfortunately I don’t foresee it happening because they’re so skittish. A shame really.
"We're all stories, in the end. Make it a good one, eh?"
- Doctor Who

Tags:
 

Related Topics

  Subject / Started by Replies Last post
6 Replies
1066 Views
Last post July 06, 2012, 10:54:49 pm
by Amethyst
4 Replies
1349 Views
Last post December 28, 2012, 05:44:08 pm
by RandallS
0 Replies
1176 Views
Last post March 14, 2014, 12:15:23 am
by mlr52
15 Replies
2175 Views
Last post May 31, 2015, 02:36:35 pm
by Caroline
1 Replies
881 Views
Last post July 17, 2018, 12:53:38 am
by Aster Breo

* Who's Online

  • Dot Guests: 42
  • Dot Hidden: 0
  • Dot Users: 5
  • Dot Users Online:

* Please Donate!

The Cauldron's server is expensive and requires monthly payments. Please become a Bronze, Silver or Gold Donor if you can. Donations are needed every month. Without member support, we can't afford the server.

* Shop & Support TC

The links below are affiliate links. When you click on one of these links you will go to the listed shopping site with The Cauldron's affiliate code. Any purchases you make during your visit will earn TC a tiny percentage of your purchase price at no extra cost to you.

* In Memoriam

Chavi (2006)
Elspeth (2010)
Marilyn (2013)

* Cauldron Staff

Host:
Sunflower

Message Board Staff
Board Coordinator:
Darkhawk

Assistant Board Coordinator:
Aster Breo

Senior Staff:
Aisling, Jenett, Sefiru

Staff:
Allaya, Chatelaine, EclecticWheel, HarpingHawke, Kylara, PerditaPickle, rocquelaire

Discord Chat Staff
Chat Coordinator:
Morag

Cauldron Council:
Bob, Catja, Emma-Eldritch, Fausta, Jubes, Kelly, LyricFox, Phouka, Sperran, Star, Steve, Tana

Site Administrator:
Randall

SimplePortal 2.3.6 © 2008-2014, SimplePortal